Infection occurs when a disease-causing germ such as a bacteria, virus or fungus invades the body. To become infected, you must catch the germ (exposure) and have the ability to become infected (susceptibility). Susceptibility is more complicated than exposure. We are all susceptible to infection by thousands of different germs. The purpose of the immune system is to prevent infection by recognizing germs and eliminating or disabling them before they can cause infection. People with immunodeficiency get the same kinds of infections that other people get—ear infections, sinusitis and pneumonia. The difference is that their infections occur more frequently, are often more severe, and have a greater risk of complications. We live in a sea of germs, and everyone gets an infection at least once in a while. However, while most people can recover on their own from most infections, some people experience recurring infections that require antibiotic treatment. Exposure and susceptibility to infections Infection occurs when a disease-causing germ, such as a bacteria, virus or fungus, invades the body. To become infected, you must catch the germ (exposure) and have the ability to become infected (susceptibility). People with a lot of contact with others, such as elementary school teachers or salespersons, are more likely to be exposed to increased numbers of germs. Susceptibility is more complicated than exposure. We are all susceptible to infection by thousands of different germs. The purpose of the immune system is to prevent infection by recognizing germs and eliminating or disabling them before they can cause infection. Remarkably, the immune system has the unique ability to learn the “face” of a germ and remember it forever. Some germ families have faces that are so similar that when your immune system learns the face of one member of the family, it protects you from infection by any member of that family. Other germ families are so different that the immune system must learn each face individually. Once your immune system has learned the face of a particular germ and successfully battled it, you are much less susceptible to infection caused by that germ. The first line of defense against infection is located where the body has contact with the rest of the world—the skin—as well as the membranes that line the respiratory system and digestive systems. Clearly, a cut on the hand is more likely to get infected than unbroken skin. Similarly, irritation, swelling and injury to the mucus membranes lining the nose, sinuses and lungs provide a fertile ground for disease-causing germs. If you have year-round allergies to dust mites, pollen and mold, you may have some injury to your mucus membranes, which can, in turn, increase your susceptibility to infection. Once a germ has entered the body, your immune system springs into action. Common infections The most common infections are viral respiratory tract infections—colds. Typically, cold symptoms last five to 10 days. If a child gets 12 colds a year, each lasting less than 10 days and usually improving without needing treatment with antibiotics, there is not usually a cause for concern. It may seem, however, that the child is sick half the time—because he or she is! These viral infections are a result of the close contact that young children have with other infected children and the fact that their immune systems are relatively immature. Once a child’s immune system learns the faces of many of the germs that cause such colds, the child will get infected less frequently. Another infection, strep throat, is also a “social disease” that children and adults catch because they are in close contact with infected individuals. Although we don’t completely understand why some people get strep throat frequently, we know that recurrent strep throat is rarely an indicator of a weak immune system. Many people confuse allergic rhinitis, or “hay fever,” which causes stuffiness, nasal itch and a runny nose that lasts for weeks, with a cold or sinus infection. Your allergist/immunologist can help you differentiate allergies from infection, or know when both are present at the same time. Once the possibility of allergy is eliminated, your allergist will consider if your infections are a simply a result of high exposure to other people with infections, or if these infections are warning signals of an immune system problem called immunodeficiency . There are many forms of immunodeficiency and while some are very severe and life-threatening, many are milder but still important enough to cause recurrent or severe infections. Signs of Immunodeficiency People with immunodeficiency get the same kinds of infections that other people get—ear infections, sinusitis and pneumonia. The difference is that their infections occur more frequently, are often more severe, and have a greater risk of complications. Furthermore, the infections usually do not go away without using antibiotics and often recur within one to two weeks after antibiotic treatment is completed. These patients frequently need many courses of antibiotics each year to stay healthy. Patients with some forms of immunodeficiency are more likely than other people to develop infections inside certain areas of the body, such as the bones, joints, liver, heart or brain. In most cases, the frequency of infection is the most important issue, but sometimes a single infection with an unusual germ is enough to trigger the need for the doctor to perform a thorough immunologic evaluation of the patient. So, how many infections are too many? Allergist/immunologists often use the frequency of the use of antibiotics to mark the frequency of significant infections. Older children and adults with healthy immune systems seldom require antibiotic treatment. However, for the reasons mentioned above, many younger children receive several courses of antibiotic therapy each year. Therefore, the number of ear infections that may be “normal” in a child under 5 years of age is clearly abnormal in older children and adults. General guidelines for determining if a patient may be experiencing too many infections are: The need for more than four courses of antibiotic treatment per year in children or more